Wilson's Disease Hair Copper Levels

Wilsons disease is caused by a mutation in the gene for a copper-binding protein.

Wilson's disease hair copper levels. However there was no increase in the copper content of hair from patients with Wilsons disease compared with those of normal subjects indicating that the high copper levels of many tissues in this disease are not reflected in hair. Also known as hepatolenticular degeneration was first described in 1912 by Kinnear Wilson as progressive lenticular degeneration a familial lethal neurological disease accompanied by chronic liver disease leading to cirrhosis. Zinc-group 2 n 8.

In this case the level of copper in the blood may be higher than normal. Treatment for Wilson disease is life-long and aimed at lowering copper levels to nontoxic levels and at preventing the progression of the disease and trying to reverse any signs and symptoms that have appeared because of copper accumulation in the body. 200 - 500µg 3 - 8µmolesday On Zinc.

It is the unbound to ceruloplasmin copper that is free to roam around the body and accumulate in organs causing Wilson disease damage. In contrast hair samples from the patient with lead poisoning showed maximum concentrations of 14 -2 micrograms g-1 compared with normal levels of less than 1 micrograms g-1. As a result copper cannot effectively bind to ceruloplasmin the copper-carrying protein that transports 95 of total copper in the body.

Approach to diagnosis of Wilson disease WD in a patient with unexplained liver disease. Janes hair mineral test revealed an extremely low copper level of 08 mg. Wilsons induces numerous types of movement-deranged symptoms similar to those of Parkinsons.

Further the composition of the hairs. The purpose of this study was to determine the different levels of copper and zinc in the serum urine and scalp hair of patients with Wilsons disease receiving different currently accepted methods of treatment to reduce the copper load penicillamine-group 1 n 8. An elevated serum copper is more often due to an elevation of the level of serum ceruloplasmin since it contains 90 of the circulating copper bound to it.

First treatment of symptomatic patients second maintenance therapy after copper has been. Very low hair copper also indicates hidden copper toxicity. It means her body has difficulty eliminating copper.